Sources and amplification have pretty much "been done" these days IMHO, unless you're talking about vinyl, where the source is electromechanical, so you have some interaction between turntable and its' suspension, the tone arm and the cartridge to play with. You can spend and spend on the latter and get little improvements. Depends where you want to stop!
Get a few competent digital sources together and you'll struggle to hear much between them. The same is true of amplification. I went to a hi-fi gathering a few weeks ago where we must have listened to half a dozen amps, both valve and solid state. Really, the only thing you could glean was slightly looser bass on some of the valve amps. Oh, and smoke coming out of one of the older solid state ones! Still sounded good, mind.
I've heard quads with both valve and solid state amplification and I think they actually work well with either. The great thing about them is that there's very little colouration in the midrange, where a conventional speaker has to have a cross over somewhere in this region, and the effects can be difficult to hide, because that's where our hearing is the most sensitive. Quads don't do the extremes of bass or treble that well, so can sound a bit "old fashioned". You can always add a tweeter to extend the HF response and the aforementioned sub, of course.
They are kinder to valve amplification because they don't need a lot of damping, something that can cause valve amps to sound a bit muddy in the bass. I've never heard valve amps deliver bass as "fast" as with ESL57s.
The most important factor is how the speaker and room interact, though, especially for dipole designs like the ESL. Put the best speaker you can buy in a room that doesn't suit it and it won't sound great.