Loads of stuff out there. Everybody will have different ideas. Personally, I once tried CC Cleaner, and it done its own thing and screwed half my stuff. Others will say its fine, and so with all others.
I am using a programme called Glary Utilities. Some one on here years ago gave us details of a lifetime licence (all legit)...not sure if I am on that still or not. The programme cleans my registry, gets out all the crap stored on the drives, etc, etc. There is a free download, but like everything, they will ask you to upgrade. Mines working fine, and never had a problem with it.
That's all I can help with, others will have other ideas