Unfortunately, what originally starts off as a noble idea, gets hijacked by vested interests. This has sadly happened to too many charities. Many are now taking EU money and will come to the aid of the EU in return, which is why you often these days see some EU propaganda endorsed by a range of UK charities. Dr Goebbels and Lord Haw Haw would be proud.
The establishment then get involved in other ways by becoming part of the management / figurehead of the charity on a vast salary or getting involved (illegally) in politics and political correctness, with a don't do what we do, do what we say attitude. In effect what a charity give to their noble cause is the profits from their operations which with far too many high profile charities these days is IMO too little.
So I will only donate to low key charities and appeals these days, where I know the majority of the money is spent on the front line and the noble cause rightly benefits.
There is much happening on the fight against cancer at the moment I recently posted a thread on using the immune system of here, but there are also an number of biotech companies, especially in the US trialing major new drugs which are going to change how view and treat cancer and other diseases.
There is also much research going on at the moment to enable people to live not only for much longer, but also to have their full health. This means that all of us are going to in the future work until we are 80 to 100 probably within our lifetime if you haven't reached retirement age yet where age span will continue to increase where living to 120 to 160 years will be the norm.
One of the reasons for our current welfare and spending crisis is an aging population where the ratio of workers, where children per couple is going down in the Western world to well below replacement rates is to solve the health problems of old age so we can continue to lead productive lives. Society is going to profoundly change with the applications of new technologies over the next 50 years. Exciting times lie ahead.
The fact that this breakthrough and completely different technology for treating cancer has come from outside the medical and pharmaceutical industries does not surprise me is as all industries 50 - 80% of breakthroughs come from outside sources. The problem when you work within and industry is that everybody tends to think in the same way, so you have evolution rather than revolutionary breakthroughs.