I have 235/40/17's on the front and 265/40/17's on the rear and I had been running mine at slightly lower pressures since I had new tyres put on as the previous tyres (rears) had shown signs of over inflation by wearing in the middle. Big Rod (the previous owner) said he had normally run them at 30psi all round, so I've been running them at 28psi.
Since then I noticed my mpg reduced to around 22 on average to and from work. I checked my pressures last night and they were slightly down on the original 28psi I put in a few weeks ago, so thought I'd try them back at 30psi as these tyres are a slightly softer compound than the last set. I reset my MID this morning and was amazed that after my 22 mile journey to work my average mpg had gone up to over 25.
It will be interesting to see what average mpg I get going to Newent this weekend. :-?
Dont forget tho Bob......the rears should be 3psi higher than the fronts on estates.....i assume that applies for your 265's as well.
I run my 225's 30 front and 33 back 
Tho my tyres take abuse......coz one min it can be just me in it......10mins later 4 15 stone passengers
I did once inflate to 33 front 36 back as a comprimise.......but overinflation wear started showing after a time.
With normal wheels and tyres I'd agree Dave, but the tyres that came off the rear were worn in the middle which would indicate over inflation. I'm going to see Tony at WIM tomorrow so I'll see what he recommends.
True. Change the tyre size and the contact patch changes in area so the pressure required will be totally different and it's best to experiment. With those hoofing great tyres on the rear I suspect the ideal pressure will be quite a bit lower on the back than the book pressure. It all depends, for each wheel, on the weight it's carrying against the area of the contact patch.
Taking the extreme example I've got 205/50/15s on my Westfield, which weighs in a tonne less than an Omega and I reckon about 17-18 PSI all round is the best pressure. I had to experiment a bit to arrive there. Putting more air in makes it feel quite taught and responsive at first, and you can go quite high on pressure with no ill effects but you realise that there's less grip if you push it, and tyre wear will eventually confirm it. If you go a pound or two under the ideal, it quickly gets a bit vague and tends to let go when pushed.
Kevin