the drill sand head will make circular and some irregular sanding traces (which I faced several times when in hurry)..
and on some bumpers of new cars cause fibers which is an headache.. (as it heats up quickly)
if you are not in hurry and have some time in hands I recommend sanding by hand..
normal procedure is removing only the paint+clear coat .. you will need to remove the prime only if you cant trust the previous job quality (ie if painted before you-not original) which in that case you will need plastic primer also as a first layer..
now which number of sand paper.. best results with 320 so will leave minimal traces (but you need to apply again some primer to close it)
if you use 150 or 220 -can be used- but you will definitely need more/thicker layers of primer and the following sanding will require more time..
please note that if there are deep scuffs you can correct them but use a block to sand and if necessary remove the primer.. plastic primer must be sprayed in those areas also..
and a final note.. in any case you will use primer .. after applying it you must wait few days for the prime to settle.. then your sanding scratches will be more visible (if any) so you will need to sand and prime again
ps: some may not agree but I always try to avoid bondo.. if used must be given proper time to dry .. even in that case it can suck the paint or fracture .. if must, use the best quality, apply as a very thin layer and give several days to dry..