Safari is simply shite under Windows, and leads to some quite "interesting" blended vulnerabilities, as such, I simply wouldn't recommend anyone use it under Windows.
Chrome is just completely broken. More holes that swiss cheese. Best avoided at all costs until Google decide to admit that it needs rebuilding from the ground up, with an eye on security.
Opera is slightly different, which makes it a bit niche. Not really that useful on a desktop, but certainly has uses on mobile devices.
Which leaves 2. IE10 and FF. Try 'em both, see how you get on. Day to day, I use IE10, due to superior speed, stability and rendering of pages. Also seems to need less patching, as MS went through all that shite in the IE5/6 days, and learnt a good security lesson that both Firefox and Chrome developers are yet to grasp. I do use FF as well, as it has some nice features for developers, but I *ALWAYS* check and update it first.
Not really much else useful out there for Windows. For Linux users, FF is the only viable choice.